Publications

Stem Cells | 2013-02-11
Co-transplantation of third-party umbilical cord blood-derived MSCs promotes engraftment in children undergoing unrelated umbilical cord blood transplantation.
This study reports that co-transplantation of Umbilical Cord Blood(UCB)-Mesenchymal Stem Cells(MSCs) in UCB transplanting patient can enhance engraftment of UCBT and decrease Transplantation Related Mortality(TRM).

· Issue information | Bone Marrow Transplant. 2013 Aug;48(8):1040-5.
· Co-author | SH Lee, MW Lee, KH Yoo, DS Kim, MH Son, KW Sung, H Cheuh, SJ Choi, W Oh, YS Yang, HH Koo.
PNEUMOSTEM | 2013-01-21
Timing of Umbilical Cord Blood Derived Mesenchymal Stem Cells Transplantation Determines Therapeutic Efficacy in the Neonatal Hyperoxic Lung Injury.
This study reports experimental results for timing of umbilical cord blood derived mesenchymal stem cells administration into airway in broncho-pulmonary dysplasia that when it is transplanted intratracheally, it is possible to obtain statistically significant therapeutic effect.

· Issue information | PLoS One. 2013;8(1):e52419.
· Co-author | YS Chang, SJ Choi, SY Ahn, DK Sung, SI Sung, HS Yoo, W Oh, WS Park.
Others | 2013-01-03
Mesenchymal Stem Cells Prevent Hydrocephalus After Severe Intraventricular Hemorrhage.
This study investigated through animal experiment that transplantation of umbilical cord blood-derived mesenchymal stem cells significantly attenuated the posthemorrhagic hydrocephalus and brain injury after IVH by the anti-inflammatory effects.

· Issue information | Stroke. 2013 Feb;44(2):497-504.
· Co-author | SY Ahn, YS Chang, DK Sung, SI Sung, HS Yoo, JH Lee, W Oh, WS Park.
NEUROSTEM | 2012-11-26
Umbilical cord blood mesenchymal stem cells protect amyloid-β42 neurotoxicity via paracrine.
This study reports that when neurons is injured by amyloid-β, a cause substance of Alzheimer type dementia, decorin and progranulin of umbilical cord blood derived mesenchymal stem cells involves in anti-apoptotic effect.

· Issue information | World J Stem Cells. Nov 26, 2012; 4(11): 110-116.
· Co-author | Ju-Yeon Kim, Dong Hyun Kim, Ji Hyun Kim, Yoon Sun Yang, Wonil Oh, Eun Hui Lee, Jong Wook Chang
NEUROSTEM | 2011-10-21
Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid β plaques.
This study demonstrates that in an Alzheimer’s type, amyloid-β developed in the hippocampus is reduced by human UCB derived MSCs. These data suggested that hUCB-MSC-derived sICAM-1 removes Aβ plaques indirectly by inducing NEP expression in microglia.

· Issue information | Cell Death Differ. 2012 Apr;19(4):680-91.
· Co-author | Kim JY, Kim DH, Kim JH, Lee D, Kim SM, Jeon HB, Kwon SJ, Choi SJ, Lee EH, Yoo YJ, Seo SW, Lee JI, Na DL, Yang YS, Oh W, Chang JW.
Others | 2011-09-01
Therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia.
This study identified in animal experiment that intrathecal administration of MSCs by lumbar puncture may be useful and feasible for MSCs treatment of ischemic brain injuries.

· Issue information | Stem Cell Res Ther. 2011 Sep 22;2(5):38.
· Co-author | Lim JY, Jeong Ch, Jun JA, Kim SM, Ryu CH, Hou Y, Oh W, Chang JW, Jeun SS.
PNEUMOSTEM | 2011-08-01
Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice.
This study shows results that intratracheal transplantation of umbilical cord blood derived mesenchymal stem cells in acute lung injury by bacteria can mitigate the injury by promoting anti-inflammatory reaction and bacterial removal.

· Issue information | Respir Res. 2011 Aug 15;12:108.
· Co-author | ES Kim, YS Chang, SJ Choi, JK Kim, HS Yoo, SY Ahn, DK Sung, SY Kim, YR Park, WS Park.
NEUROSTEM | 2011-03-31
CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas.
This study is a report that overexpression of CXCR1, one of chemokine receptor, by genetic insertion can enhance therapeutic effect of MSC in migration mechanism of hUCB-MSCs toward tumors in treating brain tumor.

· Issue information | Biochem Biophys Res Commun. 2011 Apr 22;407(4):741-6.
· Co-author | Kim SM, Kim DS, Jeong CH, Kim DH, Kim JH, Jeon HB, Kwon SJ, Jeun SS, Yang YS, Oh W, Chang JW.
NEUROSTEM | 2011-03-04
Neural Differentiation of Brain-derived Neurotrophic Factor-expressing Human Umbilical Cord Blood-derived Mesenchymal Stem Cells in Culture via TrkB-mediated ERK and β-catenin Phosphorylation and following Transplantation into the Developing Brain.
This study identified neural regeneration effect of BDNF and its mechanism in neurological disease treatment of hUCB-MSCs. The results indicate that when injecting BDNF overexpressed in hUCB-MSCs, it induces the neural differentiation of hUCB-MSCs via the phosphorylation of ERKs and β-catenin.

· Issue information | Cell Transplant. 2011;20(11-12):1855-66.
· Co-author | Lim JY, Park SI, Kim SM, Jun JA, Oh JH, Ryu CH, Jeong CH, Park SH, Park SA, Oh W, Chang JW, Jeun SS.
PNEUMOSTEM | 2011-01-01
Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Dose-Dependently Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats.
This study shows results that intratracheal transplantation of human UCB derived MSCs may attenuate hyperoxia-induced lung injury in neonatal rats by modulating host inflammatory responses and oxidative stress.

· Issue information | Cell Transplant. 2011;20(11-12):1843-54.
· Co-author | YS Chang, SJ Choi, DK Sung, SY Kim,W Oh, YS Yang, WS Park.
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