Publications

CARTISTEM | 2016-12-05
In vitro Chondrogenic Hypertrophy Induction of Mesenchymal Stem Cells
To investigate underlying mechanisms of chondrogenic hypertrophy, the inevitable result of chondrogenic differentiation of mesenchymal stem cells(MSCs), we need suitable in vitro model. This study presents a simple protocol for induction of hypertrophy during in vitro chondrogenesis of MSCs.

· Issue information | Bio-protocol. Vol 6, Issue 23, page e2057
· Co-author | Sang Young Jeong, Miyoung Lee, Soo Jin Choi, Wonil Oh, and Hong Bae Jeon
Stem Cells | 2016-03-22
Senescence associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells.
In the present study, we provide the first evidence supporting the existence of the MCP-1 as a causative contributor to human UCB-MSCs senescence and positive feedback between the intrinsic and extrinsic circuitry of the process. MCP-1 induction is epigenetically regulated by a reduction in BMI1 in senescent UCB-MSC.

· Issue information | Antioxid Redox Signal. 2015 Nov 17. doi: 10.1089/ars.2015.6359.
· Co-author | Hye Jin Jin, Hyang Ju Lee, Jisun Lim, Miyeon Kim, Min Kyung Kim, Hae Yun Nam, Gyong Hwa Hong, Yon Sook Cho, Soo Jin Choi, In-Gyu Kom, Dong-Myung Shin, Seong Who Kim
Stem Cells | 2016-03-03
Downregulation of Melanoma Cell Adhesion Molecule(MCAM/CD146) Accelerates Cellular Senescence in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.
This study provides strong evidence that CD146 is a novel and useful marker for predicting senescence in human UCB-MSCs, and CD146 can potentially be applied in quality-control assessments of human UCB-MSC-based therapy.

· Issue information | Stem Cells Transl Med. 2016 Apr;5(4):427-39.
· Co-author | Hye Jin Jin, Ji Hye Kwon, Miyeon Kim, Yun Kyung Bae, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon
CARTISTEM | 2015-08-25
Autocrine Action of Thrombospondin-2 Determines the Chondrogenic Differentiation Potential and Suppresses Hypertrophic Maturation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.
This study indicates that the variable chondrogenic differentiation potential of human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) obtained from different donors is influenced by the thrombospondin-2(TSP-2) level. Additionally, TSP-2 could attenuate hypertrophy during chondrogenic differentiation of hUCB-MSCs. Thus, TSP-2 can be used as a marker to select MSCs with superior chondrogenic differentiation potential for cartilage regeneration therapy.

· Issue information | Stem Cells. 2015 Nov;33(11):3291-303. doi: 10.1002/stem.2120. Epub 2015 Aug 25.
· Co-author | Sang Young Jeong, Jueun Ha, Miyoung Lee, Hye Jin Jin, Dong Hyun Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jae-Sung Kim, Byung-Gyu Kim, Jeong Ho Chang, Dong-Hyung Cho, Hong Bae Jeon
NEUROSTEM | 2015-08-19
GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer’s disease model.
In this study, we elucidated that the effectiveness to repeatedly administrated hUCB-MSCs through the CSF route as well as the promotion of hippocampal neurogenesis and synaptic activity by the GDF-15 secreted from hUCB-MSCs in Alzheimer's disease model.

· Issue information | Stem Cells Dev. 2015 Oct 15;24(20):2378-90. doi: 10.1089/scd.2014.0487. Epub 2015 Aug 19.
· Co-author | Dong Hyun Kim, Dahm Lee, Eun Hyuk Chang, Ji Hyun Kim, Jung Won Hwang, Ju-Yeon Kim, Jae Won Kyung, Sung Hyun Kim, Jeong Su Oh, Sang Mi Shim, Duk Lyul Na, Wonil Oh, Jong Wook Chang
Others | 2015-05-29
Conditioned Media from Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Inhibits Melanogenesis by Promoting Proteasomal Degradation of MITF.
This study showed that conditioned media from human umbilical cord blood-derived mesenchymal stem cells inhibits melanogenesis by modulating microphthalmia-associated transcription factor(MITF) via ERK signaling pathway.

· Issue information | PLoS One. 2015 May 29;10(5):e0128078. doi: 10.1371/journal.pone.0128078. eCollection 2015.
· Co-author | Kim ES, Jeon HB, Lim H, Shin JH, Park SJ, Jo YK, Oh W, Yang YS, Cho DH, Kim JY.
Stem Cells | 2014-01-11
Optimization of the therapeutic efficacy of human umbilical cord blood-mesenchymal stromal cells in an NSG mouse xenograft model of graft-versus-host disease
This is a study to identify optimal conditions for improving therapeutic effectiveness of human umbilical cord blood mesenchymal stem cells in prevention or treatment of GVHD(Graft-versus-Host Disease).

· Issue information | Cytotherapy. 2014 Mar;16(3):298-308.
· Co-author | Yun Kyung Jang, Miyeon Kim, Young-Ho Lee, Wonil Oh, Yoon Sun Yang & Soo Jin Choi.
CARTISTEM | 2013-10-01
Thrombospondin-2 secreted by human umbilical cord blood-derived mesenchymal stem cells promotes chondrogenic differentiation.
Although therapeutic effect of mesenchymal stem cells on cartilage disorders is well known, a lot of studies are being progressed on its mechanism. In this study, a specific protein (TSP-2) expressed by cord blood mesenchymal cells by joint fluid component was identified and the regeneration mechanism of injured cartilage was determined by secretion of this protein.

· Issue information | Stem Cells. 2013 Oct;31(10):2136-48.
· Co-author | Jeong SY, Kim DH, Ha J, Jin HJ, Kwon SJ, Chang JW, Choi SJ, Oh W, Yang YS, Kim G, Kim JS, Yoon JR, Cho DH, Jeon HB.
Stem Cells | 2013-09-03
Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy.
Mesenchymal stem cells are isolated and cultured from various sources such as bone marrow, cord blood and fat. This study compared surface antigen expression, differentiation ability, proliferation capacity, clonality, tolerance for aging, and paracrine activity and identified a protein effective to treatment inflammation from cord blood derived mesenchymal stem cell.

· Issue information | Int. J. Mol. Sci. 2013, 14(9), 17986-18001.
· Co-author | Hye Jin Jin, Yun Kyung Bae, Miyeon Kim, Soon-Jae Kwon, Hong Bae Jeon, Soo Jin Choi, Seong Who Kim, Yoon Sun Yang, Wonil Oh, Jong Wook Chang.
Cord Blood | 2013-08-01
Cryopreserved Cord Blood Progenitors and Their Cell Adhesion Molecules Are Increased by Coculture With Osteoblasts and Parathyroid Hormone.
Despite the cord blood(CB) cells induces lower immunogenicity, CB transplantation is also associated with delayed neutrophil and platelet recovery relative to bone marrow transplantation. This suggests a possibility to increase the engraftment of hematopoietic cells in CB by increasing the abundances of primitive cells bearing adhesion molecules in the presence of hPTH.

· Issue information | J Pediatr Hematol Oncol. 2013. Aug;35(6):e229-e233.
· Co-author | Yun Kyung Jang, Miyeon Kim, Hye Jin Jin,Soo Jin Choi, Wonil Oh, and Young-Ho Lee
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