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Cobalt Chloride Enhances the Anti-Inflammatory Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells through the

Stem Cells
Date
2018-09-05 17:35
Views
11
Issue information : 2018 Sep 5;2018:4978763. doi: 10.1155/2018/4978763

Co-author : Ji Hye Kwak, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon, Eun Su Jeon


MSC shows therapeutic effects through paracrine secretion or intercellular contact that regulates inflammatory or immune responses. Through the asthma mouse model, this study showed that CoCl2 enhances the anti-inflammatory activity of MSC through the ERK-HIF-1a-miRNA124a pathway, and CoCl2 has better therapeutic efficacy for inflammatory diseases of pretreated MSC.
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