Effect of growth differentiation factor-15 secreted by human umbilical cord blood- derived mesenchymal stem cells on amyloid be

2018-10-12 17:36
Issue information : 2018 Oct 12;504(4):933-940. doi: 10.1016/j.bbrc.2018.09.012. Epub 2018 Sep 14.

Co-author : Dong Hyun Kim, Dahm Lee, Hoon Lim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jong Ho Jang

This study demonstrated in an Alzheimer's disease model that secretory protein of umbilical cord blood-derived mesenchymal stem cells, GDF-15 promotes the removal of amyloid beta by improving the secretion of IDE(insulin-degrading enzyme) well-known as a representative amyloid-degrading enzyme through the regulation of microglia in the nervous system. This study is meaningful in that it further clarified that previously reported GDF-15 is effective in promoting amyloid beta removal in addition to the nerve regeneration effect as a role of multi-function.