Autocrine Action of Thrombospondin-2 Determines the Chondrogenic Differentiation Potential and Suppresses Hypertrophic Maturati

2015-08-25 17:24
Issue information : Stem Cells. 2015 Nov;33(11):3291-303. doi: 10.1002/stem.2120. Epub 2015 Aug 25.

Co-author : Sang Young Jeong, Jueun Ha, Miyoung Lee, Hye Jin Jin, Dong Hyun Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jae-Sung Kim, Byung-Gyu Kim, Jeong Ho Chang, Dong-Hyung Cho, Hong Bae Jeon

This study indicates that the variable chondrogenic differentiation potential of human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) obtained from different donors is influenced by the thrombospondin-2(TSP-2) level. Additionally, TSP-2 could attenuate hypertrophy during chondrogenic differentiation of hUCB-MSCs. Thus, TSP-2 can be used as a marker to select MSCs with superior chondrogenic differentiation potential for cartilage regeneration therapy.