Publications
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Stem Cells | 2009-04-01 Overexpression of CXC chemokine receptors is required for the superior glioma- tracking property of umbilical cord blood-derived mesenchymal stem cells.
This study suggests that glioma cells secretes IL-8 and GRO-alpha and hUCB-MSCs expressing receptors to them, CXCR-1, 2, are effective in glioma therapy.· Issue information | Stem Cells Dev. 2009 Apr;18(3):511-9. · Co-author | Kim DS, Kim JH, Lee JK, Choi SJ, Kim JS, Jeun SS, Oh W, Yang YS, Chang JW. |
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Stem Cells | 2008-12-01 Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
This study proves that hUCB-MSCs play a role as a useful delivery vehicle in gene transfer therapy against intracranial glioma.· Issue information | Cancer Res. 2008 Dec 1;68(23):9614-23. · Co-author | Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS. |
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Stem Cells | 2008-08-01 Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways.
This study are results confirming signaling in neuronal differentiation of hUCB-MSCs by BDNF.· Issue information | J Neurosci Res. 2008 Aug 1;86(10):2168-78. · Co-author | Lim JY, Park SI, Oh JH, Kim SM, Jeong CH, Jun JA, Lee KS, Oh W, Lee JK, Jeun SS. |
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Stem Cells | 2008-02-01 Cytotoxicity of human umbilical cord blood-derived mesenchymal stem cells against human malignant glioma cells.
This is a study confirming whether hUCB-MSCs without external cell activation show cytotoxicity to malignant glioma, using hUCB-MSCs with tropism toward brain tumor cells.· Issue information | Childs Nerv Syst. 2008 Mar;24(3):293-302. · Co-author | Kang SG, Jeun SS, Lim JY, Kim SM, Yang YS, Oh WI, Huh PW, Park CK. |
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Stem Cells | 2008-02-01 Immunological properties of umbilical cord blood-derived mesenchymal stromal cells.
Explaining immunological properties of hUCB-MSCs, this study shows that hUCB-MSCs have no antigen inducing immune response and can control immune response, so they are proper to allogenic cell therapy.· Issue information | Cell Immunol. 2008 Feb;251(2):116-23. · Co-author | Oh W, Kim DS, Yang YS, Lee JK. |
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Stem Cells | 2007-01-01 Effect of Aging on the Pluripotential Capacity of Human Bone Marrow Derived Mesenchymal Stem Cells.
This study is a review on clinical applicability of hUCB-MSCs, comparing differentiation ability of hUCB-MSCs according to age.· Issue information | J Korean Orthop Assoc, 42: 701-710, 2007. · Co-author | Jin HJ, Choi SJ, Bae YK, Lee SY, Gil MO, Park CM, Wang JH, Oh WI, Yang YS, Cho IH, Kim CG, Song HR. |
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Stem Cells | 2006-12-01 Cotransplanted Bone Marrow Derived Mesenchymal Stem Cells(MSC) Enhanced Engraftment of Hematopoietic Stem Cells in a MSC-dose Dependent Manner in NOD/SCID Mice.
This study presented results of animal experiment that co-transplantation of bone marrow derived MSCs combined with human hematopoietic cells can enhance engraftment of hematopoietic cells and effective concentration of MSCs.· Issue information | Journal of Korean Medical Sciences 2006, 21(6): 1000~1004. · Co-author | Kim DH, Yoo KH, Yim YS, Choi J, Lee SH, Jung HL, Sung KW, Yang SE, Oh WI, Yang YS, Kim SH, Choi SY, Koo HH. |
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Stem Cells | 2006-04-01 Mesenchymal stem cells feeder layer from human umbilical cord blood for ex vivo expanded growth and proliferation of hematopoietic progenitor cells.
Human umbilical cord blood has disadvantages such as delayed engraftment of neutrophils and platelets than bone marrow in transplantation of hematopoietic cells. This study presented a method to complement shortcomings of hUCB derived hematopoietic cells by using cytokine secretion ability of hUCB-MSCs.· Issue information | Ann Hematol. 2006 Apr;85(4):212-25. · Co-author | Yun Kyung Jang, Dai Hyun Jung, Mee Hyun Jung, Dong Hyun Kim, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Wonil Oh, Yoon Sung Yang, Sung-Eun Yang. |
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Stem Cells | 2005-07-21 Gene expression profile of cytokine and growth factor during differentiation of bone marrow-derived mesenchymal stem cell.
This study prepared basic data that could consider future clinical applications of MSCs through cytokine profiling of MSCs.· Issue information | Cytokine 2005; 31: 119-26. · Co-author | DH Kim, KH Yoo, KS Choi, J Choi, SY Choi, SE Yang, YS Yang, HJ Im, KH Kim, HL Jung, KW Sung, HH Koo. |
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Stem Cells | 2005-01-04 Isolation, Characterization and Tri-lineage Differentiation of Mesenchymal Stem Cells from Human Umbilical Cord Blood.
This study showed that it was possible to isolate and culture MSCs from hUCB by verifying cell surface antigen and differentiation ability of MSCs isolated and cultured from hUCB.· Issue information | The Journal of the Korean Orthopaedic Association(2004) Vol.39, Page : 537 ~ 545. · Co-author | Sung-Eun Yang, Yoon-Sun Yang, Chul-Won Ha |