Senescence associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells.

Stem Cells
2016-03-22 17:26
Issue information : Antioxid Redox Signal. 2015 Nov 17. doi: 10.1089/ars.2015.6359.

Co-author : Hye Jin Jin, Hyang Ju Lee, Jisun Lim, Miyeon Kim, Min Kyung Kim, Hae Yun Nam, Gyong Hwa Hong, Yon Sook Cho, Soo Jin Choi, In-Gyu Kom, Dong-Myung Shin, Seong Who Kim

In the present study, we provide the first evidence supporting the existence of the MCP-1 as a causative contributor to human UCB-MSCs senescence and positive feedback between the intrinsic and extrinsic circuitry of the process. MCP-1 induction is epigenetically regulated by a reduction in BMI1 in senescent UCB-MSC.