Publications

NEUROSTEM | 2018-10-12
Effect of growth differentiation factor-15 secreted by human umbilical cord blood- derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer's disease
This study demonstrated in an Alzheimer's disease model that secretory protein of umbilical cord blood-derived mesenchymal stem cells, GDF-15 promotes the removal of amyloid beta by improving the secretion of IDE(insulin-degrading enzyme) well-known as a representative amyloid-degrading enzyme through the regulation of microglia in the nervous system. This study is meaningful in that it further clarified that previously reported GDF-15 is effective in promoting amyloid beta removal in addition to the nerve regeneration effect as a role of multi-function.

· Issue information | 2018 Oct 12;504(4):933-940. doi: 10.1016/j.bbrc.2018.09.012. Epub 2018 Sep 14.
· Co-author | Dong Hyun Kim, Dahm Lee, Hoon Lim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jong Ho Jang
NEUROSTEM | 2018-01-10
Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer’s disease model
This study shows that TSP-1, a secretory protein of umbilical cord blood-derived mesenchymal stem cells, can restore nerve cell synapse dysfunction in Alzheimer-type dementia.

· Issue information | Sci Rep. 2018 Jan 10;8(1):354. doi: 10.1038/s41598-017-18542-0.
· Co-author | Dong Hyun Kim, Hoon Lim, Dahm Lee, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jeong Soo Oh, Hyun Ho Hwang, Hong Bae Jeon
NEUROSTEM | 2015-08-19
GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer’s disease model.
In this study, we elucidated that the effectiveness to repeatedly administrated hUCB-MSCs through the CSF route as well as the promotion of hippocampal neurogenesis and synaptic activity by the GDF-15 secreted from hUCB-MSCs in Alzheimer's disease model.

· Issue information | Stem Cells Dev. 2015 Oct 15;24(20):2378-90. doi: 10.1089/scd.2014.0487. Epub 2015 Aug 19.
· Co-author | Dong Hyun Kim, Dahm Lee, Eun Hyuk Chang, Ji Hyun Kim, Jung Won Hwang, Ju-Yeon Kim, Jae Won Kyung, Sung Hyun Kim, Jeong Su Oh, Sang Mi Shim, Duk Lyul Na, Wonil Oh, Jong Wook Chang
NEUROSTEM | 2012-11-26
Umbilical cord blood mesenchymal stem cells protect amyloid-β42 neurotoxicity via paracrine.
This study reports that when neurons is injured by amyloid-β, a cause substance of Alzheimer type dementia, decorin and progranulin of umbilical cord blood derived mesenchymal stem cells involves in anti-apoptotic effect.

· Issue information | World J Stem Cells. Nov 26, 2012; 4(11): 110-116.
· Co-author | Ju-Yeon Kim, Dong Hyun Kim, Ji Hyun Kim, Yoon Sun Yang, Wonil Oh, Eun Hui Lee, Jong Wook Chang
NEUROSTEM | 2011-10-21
Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid β plaques.
This study demonstrates that in an Alzheimer’s type, amyloid-β developed in the hippocampus is reduced by human UCB derived MSCs. These data suggested that hUCB-MSC-derived sICAM-1 removes Aβ plaques indirectly by inducing NEP expression in microglia.

· Issue information | Cell Death Differ. 2012 Apr;19(4):680-91.
· Co-author | Kim JY, Kim DH, Kim JH, Lee D, Kim SM, Jeon HB, Kwon SJ, Choi SJ, Lee EH, Yoo YJ, Seo SW, Lee JI, Na DL, Yang YS, Oh W, Chang JW.
NEUROSTEM | 2011-03-31
CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas.
This study is a report that overexpression of CXCR1, one of chemokine receptor, by genetic insertion can enhance therapeutic effect of MSC in migration mechanism of hUCB-MSCs toward tumors in treating brain tumor.

· Issue information | Biochem Biophys Res Commun. 2011 Apr 22;407(4):741-6.
· Co-author | Kim SM, Kim DS, Jeong CH, Kim DH, Kim JH, Jeon HB, Kwon SJ, Jeun SS, Yang YS, Oh W, Chang JW.
NEUROSTEM | 2011-03-04
Neural Differentiation of Brain-derived Neurotrophic Factor-expressing Human Umbilical Cord Blood-derived Mesenchymal Stem Cells in Culture via TrkB-mediated ERK and β-catenin Phosphorylation and following Transplantation into the Developing Brain.
This study identified neural regeneration effect of BDNF and its mechanism in neurological disease treatment of hUCB-MSCs. The results indicate that when injecting BDNF overexpressed in hUCB-MSCs, it induces the neural differentiation of hUCB-MSCs via the phosphorylation of ERKs and β-catenin.

· Issue information | Cell Transplant. 2011;20(11-12):1855-66.
· Co-author | Lim JY, Park SI, Kim SM, Jun JA, Oh JH, Ryu CH, Jeong CH, Park SH, Park SA, Oh W, Chang JW, Jeun SS.
NEUROSTEM | 2010-12-01
Irradiation enhances the tumor tropism and therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand-secreting human umbilical cord blood-derived mesenchymal stem cells in glioma therapy.
This study proved that when irradiation was added to brain tumor therapy, tumor tropism of hUCB-MSCs into which TRAIL gene inducing apoptosis was introduced was increased to enhance its therapeutic effect.

· Issue information | Stem Cells. 2010 Dec;28(12):2217-28.
· Co-author | Kim SM, Oh JH, Park SA, Ryu CH, Lim JY, Kim DS, Chang JW, Oh W, Jeun SS.
NEUROSTEM | 2010-08-01
Galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces amyloid-beta42 neurotoxicity in vitro.
This study shows that galectin-3(GAL-3), a protein secreted from hUCB-MSCs, protects neurons from toxicity of amyloid-β, a cause substance of Alzheimer type dementia.

· Issue information | FEBS Lett. 2010 Aug 20;584(16):3601-8.
· Co-author | Kim JY, Kim DH, Kim DS, Kim JH, Jeong SY, Jeon HB, Lee EH, Yang YS, Oh W, Chang JW.
NEUROSTEM | 2009-04-01
Overexpression of CXC chemokine receptors is required for the superior glioma- tracking property of umbilical cord blood-derived mesenchymal stem cells.
This study suggests that glioma cells secretes IL-8 and GRO-alpha and hUCB-MSCs expressing receptors to them, CXCR-1, 2, are effective in glioma therapy.

· Issue information | Stem Cells Dev. 2009 Apr;18(3):511-9.
· Co-author | Kim DS, Kim JH, Lee JK, Choi SJ, Kim JS, Jeun SS, Oh W, Yang YS, Chang JW.
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