| Stem Cells | 2018-10-12|
Effect of growth differentiation factor-15 secreted by human umbilical cord blood- derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer's diseaseThis study demonstrated in an Alzheimer's disease model that secretory protein of umbilical cord blood-derived mesenchymal stem cells, GDF-15 promotes the removal of amyloid beta by improving the secretion of IDE(insulin-degrading enzyme) well-known as a representative amyloid-degrading enzyme through the regulation of microglia in the nervous system. This study is meaningful in that it further clarified that previously reported GDF-15 is effective in promoting amyloid beta removal in addition to the nerve regeneration effect as a role of multi-function.
· Issue information | 2018 Oct 12;504(4):933-940. doi: 10.1016/j.bbrc.2018.09.012. Epub 2018 Sep 14.
· Co-author | Dong Hyun Kim, Dahm Lee, Hoon Lim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jong Ho Jang
| Stem Cells | 2018-09-05|
Cobalt Chloride Enhances the Anti-Inflammatory Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells through the ERK-HIF-1α-MicroRNA-146a-Mediated Signaling PathwayMSC shows therapeutic effects through paracrine secretion or intercellular contact that regulates inflammatory or immune responses. Through the asthma mouse model, this study showed that CoCl2 enhances the anti-inflammatory activity of MSC through the ERK-HIF-1a-miRNA124a pathway, and CoCl2 has better therapeutic efficacy for inflammatory diseases of pretreated MSC.
· Issue information | 2018 Sep 5;2018:4978763. doi: 10.1155/2018/4978763
· Co-author | Ji Hye Kwak, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon, Eun Su Jeon
| Others | 2018-08-06|
Modeling and Staging of Osteoarthritis Progression Using Serial CT Imaging and ArthroscopyThis study presents an animal model of degenerative arthritis similar to humans in which the meniscal release method can be used to induce degenerative arthritis in sheep and then, the degree of cartilage damage can be checked with CT images and arthroscopy without the sacrifice of the object to determine when to administer the therapeutic agent.
· Issue information | Cartilage. 2018 Aug 6:1947603518789997. doi: 10.1177/1947603518789997
· Co-author | Candace Flynn, Mark Hurtig, Emma Lamoure, Erin Cummins, Valeria Roati, Mark Lowerison, Sang Young Jeong, Wonil Oh, Alex Zur Linden
| Stem Cells | 2018-07-11|
Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/β-Catenin Signaling PathwayCalcium enhances the ability of cord blood-derived stem cells to differentiate into fat, which is observed through Wnt5a / β-Catenin signaling. Culture conditions to improve stem cell differentiation potency were identified through the above results.
· Issue information | Stem Cells Int. 2018 Jul 11;2018:6545071. doi: 10.1155/2018/6545071
· Co-author | Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hye Jin Jin, Hong Bae Jeon
| Stem Cells | 2018-05-22|
Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host diseaseThe superiority of the new process SMUP cells was identified and the efficacy enhancement of the cell therapy products was demonstrated through the GVHD animal model. Basic data for cell therapy products development was obtained through the new process.
· Issue information | Leukemia. 2018 May 22. doi: 10.1038/s41375-018-0151-8
· Co-author | Hye Jin Jin, Sang Young Jeong, JiHye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hyun Ho Hwang, Hong Bae Jeon
| Stem Cells | 2018-01-10|
Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer’s disease modelThis study shows that TSP-1, a secretory protein of umbilical cord blood-derived mesenchymal stem cells, can restore nerve cell synapse dysfunction in Alzheimer-type dementia.
· Issue information | Sci Rep. 2018 Jan 10;8(1):354. doi: 10.1038/s41598-017-18542-0.
· Co-author | Dong Hyun Kim, Hoon Lim, Dahm Lee, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jeong Soo Oh, Hyun Ho Hwang, Hong Bae Jeon
| Stem Cells | 2017-10-10|
Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cellsAs a study on the optimal condition and large capacity cell culture method for the clinical application of mesenchymal stem cells, this study demonstrates that it maintains stem cell characteristics with an increasing number of cells.
· Issue information | Clin Transl Med. 2017 Oct 10;6(1):38. doi: 10.1186/s40169-017-0168-z.
· Co-author | Wankyu Choi, Soon Jea Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon, Eun Su Jeon
| PNEUMOSTEM | 2017-04-21|
Two-Year Follow-Up Outcomes of Premature Infants Enrolled in the Phase I Trial of Mesenchymal Stem Cells Transplantation for Bronchopulmonary DysplasiaIntratracheal transplantation of PNEMOSTEM in preterm infants enrolled in the Phase I Trial has been shown to be safe, with no adverse respiratory, growth, and neurodevelopmental effects at 2 years follow-up.
· Issue information | J Pediatr. 2017 Jun;185:49-54.e2. doi: 10.1016/j.jpeds.2017.02.061
· Co-author | So Yoon Ahn, Yun Sil Chang, Ji Hye Kim, Se In Sung, Won Soon Park
| CARTISTEM | 2017-02-02|
Restoration of a large osteochondral defect of the knee using a composite of umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-upCARTISTEM implantation showed cartilage regeneration and improving clinical outcomes in one patient for large osteochondral defects of the knee at 5 years follow-up.
· Issue information | BMC Musculoskelet Disord. 2017 Feb 2;18(1):59-68. doi: 10.1186/s12891-017-1422-7.
· Co-author | Yong-Beom Park, Chul-Won Ha, Choong-Hee Lee, Yong-Geun Park
| CARTISTEM | 2016-12-05|
In vitro Chondrogenic Hypertrophy Induction of Mesenchymal Stem CellsTo investigate underlying mechanisms of chondrogenic hypertrophy, the inevitable result of chondrogenic differentiation of mesenchymal stem cells(MSCs), we need suitable in vitro model. This study presents a simple protocol for induction of hypertrophy during in vitro chondrogenesis of MSCs.
· Issue information | Bio-protocol. Vol 6, Issue 23, page e2057
· Co-author | Sang Young Jeong, Miyoung Lee, Soo Jin Choi, Wonil Oh, and Hong Bae Jeon