Publications

Stem Cells | 2022-02-01
CD26 Inhibition Potentiates the Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence
CD26 is a potential novel target for the rejuvenation of senescent MSCs for their use in manufacturing MSC-based applications.

· Issue information | Front Cell Dev Biol. 2021; 9: 803645. Published online 2022 Feb 1. doi: 10.3389/fcell.2021.803645
· Co-author | Miyeon Kim, Jinyoung Go, Ji Hye Kwon, Hye Jin Jin, Yun Kyung Bae, Eun-Young Kim, Eun-Ju Chang, Soo Jin Choi and Seong Who Kim
Stem Cells | 2021-04-15
Positively correlated CD47 activation and autophagy in umbilical cord blood-derived mesenchymal stem cells during senescence
CD47 is a key player in autophagy and senescence to maintain and regulate the growth of MSCs, suggesting that CD47 may be a critical key marker for selection of effective stem cells in cell therapy.

· Issue information | Stem Cells Int. 2021 Apr 15;2021:5582792. doi: 10.1155/2021/5582792.
· Co-author | Gee-Hye Kim, Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Soyoun Um and Hye Jin Jin
Stem Cells | 2020-12-26
Prospects for the therapeutic development of umbilical cord blood-derived mesenchymal stem cells.
This article reviewed the current literature pertaining to the UCB-derived MSC application as potential treatment strategies, and discuss the concerns regarding the safety and mass production issues in future applications.

· Issue information | World J Stem Cells. 2020 Dec 26;12(12):1511-1528. doi: 10.4252/wjsc.v12.i12.1511.
· Co-author | Soyoun Um, Jueun Ha, Soo Jin Choi, Wonil Oh, Hye Jin Jin
Stem Cells | 2020-07-18
Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Aberrant Tau Phosphorylation in an Alzheimer Disease Model
hUCB-MSCs-secreted GAL-3 reduces Aberrant tau phosphorylation in AD model

· Issue information | Stem Cells Int. 2020 Jul 18;2020:8878412.doi:10.1155/2020/8878412
· Co-author | Hoon Lim, Dahm Lee, Wan Kyu Choi, Soo Jin Choi, Wonil Oh, Dong Hyun Kim
Stem Cells | 2020-04-17
Primary cilia mediate Wnt5a/β-catenin signaling to regulate adipogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells following calcium induction
Ciliogenesis was negatively regulated by Wnt5a/β-catenin signaling during adipogenesis.

· Issue information | Tissue Eng Regen Med. 2020 Apr;17(2):193-202. doi: 10.1007/s13770-019-00237-4.
· Co-author | Yun Kyung Bae, Gee-Hye Kim, Ji Hye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin
Stem Cells | 2020-01-11
Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid Formation Promotes Therapeutic Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
The increase in SOD2 in the spheroid form of MSCs is a particularly relevant finding relative to the improvement of therapeutic potency by enhancing cell survival and suppressing the oxidative stress in osteoarthritis.

· Issue information | Antioxidants 2020, 9(1), 66; https://doi.org/10.3390/antiox901066
· Co-author | Miyoung Lee, Bo Ram Song, Dong Hyun Kim, Jueun Ha, Minju Lee, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin
Stem Cells | 2018-10-12
Effect of growth differentiation factor-15 secreted by human umbilical cord blood- derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer's disease
This study demonstrated in an Alzheimer's disease model that secretory protein of umbilical cord blood-derived mesenchymal stem cells, GDF-15 promotes the removal of amyloid beta by improving the secretion of IDE(insulin-degrading enzyme) well-known as a representative amyloid-degrading enzyme through the regulation of microglia in the nervous system. This study is meaningful in that it further clarified that previously reported GDF-15 is effective in promoting amyloid beta removal in addition to the nerve regeneration effect as a role of multi-function.

· Issue information | 2018 Oct 12;504(4):933-940. doi: 10.1016/j.bbrc.2018.09.012. Epub 2018 Sep 14.
· Co-author | Dong Hyun Kim, Dahm Lee, Hoon Lim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jong Ho Jang
Stem Cells | 2018-09-05
Cobalt Chloride Enhances the Anti-Inflammatory Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells through the ERK-HIF-1α-MicroRNA-146a-Mediated Signaling Pathway
MSC shows therapeutic effects through paracrine secretion or intercellular contact that regulates inflammatory or immune responses. Through the asthma mouse model, this study showed that CoCl2 enhances the anti-inflammatory activity of MSC through the ERK-HIF-1a-miRNA124a pathway, and CoCl2 has better therapeutic efficacy for inflammatory diseases of pretreated MSC.

· Issue information | 2018 Sep 5;2018:4978763. doi: 10.1155/2018/4978763
· Co-author | Ji Hye Kwak, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon, Eun Su Jeon
Stem Cells | 2018-07-11
Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/β-Catenin Signaling Pathway
Calcium enhances the ability of cord blood-derived stem cells to differentiate into fat, which is observed through Wnt5a / β-Catenin signaling. Culture conditions to improve stem cell differentiation potency were identified through the above results.

· Issue information | Stem Cells Int. 2018 Jul 11;2018:6545071. doi: 10.1155/2018/6545071
· Co-author | Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hye Jin Jin, Hong Bae Jeon
Stem Cells | 2018-05-22
Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease
The superiority of the new process SMUP cells was identified and the efficacy enhancement of the cell therapy products was demonstrated through the GVHD animal model. Basic data for cell therapy products development was obtained through the new process.

· Issue information | Leukemia. 2018 May 22. doi: 10.1038/s41375-018-0151-8
· Co-author | Hye Jin Jin, Sang Young Jeong, JiHye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hyun Ho Hwang, Hong Bae Jeon