Stem Cells | 2020-01-11
Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid Formation Promotes Therapeutic Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
The increase in SOD2 in the spheroid form of MSCs is a particularly relevant finding relative to the improvement of therapeutic potency by enhancing cell survival and suppressing the oxidative stress in osteoarthritis.

· Issue information | Antioxidants 2020, 9(1), 66;
· Co-author | Miyoung Lee, Bo Ram Song, Dong Hyun Kim, Jueun Ha, Minju Lee, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin
Stem Cells | 2018-09-05
Cobalt Chloride Enhances the Anti-Inflammatory Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells through the ERK-HIF-1α-MicroRNA-146a-Mediated Signaling Pathway
MSC shows therapeutic effects through paracrine secretion or intercellular contact that regulates inflammatory or immune responses. Through the asthma mouse model, this study showed that CoCl2 enhances the anti-inflammatory activity of MSC through the ERK-HIF-1a-miRNA124a pathway, and CoCl2 has better therapeutic efficacy for inflammatory diseases of pretreated MSC.

· Issue information | 2018 Sep 5;2018:4978763. doi: 10.1155/2018/4978763
· Co-author | Ji Hye Kwak, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon, Eun Su Jeon
Stem Cells | 2018-07-11
Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/β-Catenin Signaling Pathway
Calcium enhances the ability of cord blood-derived stem cells to differentiate into fat, which is observed through Wnt5a / β-Catenin signaling. Culture conditions to improve stem cell differentiation potency were identified through the above results.

· Issue information | Stem Cells Int. 2018 Jul 11;2018:6545071. doi: 10.1155/2018/6545071
· Co-author | Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hye Jin Jin, Hong Bae Jeon
Stem Cells | 2018-05-22
Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease
The superiority of the new process SMUP cells was identified and the efficacy enhancement of the cell therapy products was demonstrated through the GVHD animal model. Basic data for cell therapy products development was obtained through the new process.

· Issue information | Leukemia. 2018 May 22. doi: 10.1038/s41375-018-0151-8
· Co-author | Hye Jin Jin, Sang Young Jeong, JiHye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hyun Ho Hwang, Hong Bae Jeon
Stem Cells | 2017-10-10
Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cells
As a study on the optimal condition and large capacity cell culture method for the clinical application of mesenchymal stem cells, this study demonstrates that it maintains stem cell characteristics with an increasing number of cells.

· Issue information | Clin Transl Med. 2017 Oct 10;6(1):38. doi: 10.1186/s40169-017-0168-z.
· Co-author | Wankyu Choi, Soon Jea Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon, Eun Su Jeon
Stem Cells | 2016-03-22
Senescence associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells.
In the present study, we provide the first evidence supporting the existence of the MCP-1 as a causative contributor to human UCB-MSCs senescence and positive feedback between the intrinsic and extrinsic circuitry of the process. MCP-1 induction is epigenetically regulated by a reduction in BMI1 in senescent UCB-MSC.

· Issue information | Antioxid Redox Signal. 2015 Nov 17. doi: 10.1089/ars.2015.6359.
· Co-author | Hye Jin Jin, Hyang Ju Lee, Jisun Lim, Miyeon Kim, Min Kyung Kim, Hae Yun Nam, Gyong Hwa Hong, Yon Sook Cho, Soo Jin Choi, In-Gyu Kom, Dong-Myung Shin, Seong Who Kim
Stem Cells | 2016-03-03
Downregulation of Melanoma Cell Adhesion Molecule(MCAM/CD146) Accelerates Cellular Senescence in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.
This study provides strong evidence that CD146 is a novel and useful marker for predicting senescence in human UCB-MSCs, and CD146 can potentially be applied in quality-control assessments of human UCB-MSC-based therapy.

· Issue information | Stem Cells Transl Med. 2016 Apr;5(4):427-39.
· Co-author | Hye Jin Jin, Ji Hye Kwon, Miyeon Kim, Yun Kyung Bae, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon
Stem Cells | 2014-01-11
Optimization of the therapeutic efficacy of human umbilical cord blood-mesenchymal stromal cells in an NSG mouse xenograft model of graft-versus-host disease
This is a study to identify optimal conditions for improving therapeutic effectiveness of human umbilical cord blood mesenchymal stem cells in prevention or treatment of GVHD(Graft-versus-Host Disease).

· Issue information | Cytotherapy. 2014 Mar;16(3):298-308.
· Co-author | Yun Kyung Jang, Miyeon Kim, Young-Ho Lee, Wonil Oh, Yoon Sun Yang & Soo Jin Choi.
Stem Cells | 2013-09-03
Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy.
Mesenchymal stem cells are isolated and cultured from various sources such as bone marrow, cord blood and fat. This study compared surface antigen expression, differentiation ability, proliferation capacity, clonality, tolerance for aging, and paracrine activity and identified a protein effective to treatment inflammation from cord blood derived mesenchymal stem cell.

· Issue information | Int. J. Mol. Sci. 2013, 14(9), 17986-18001.
· Co-author | Hye Jin Jin, Yun Kyung Bae, Miyeon Kim, Soon-Jae Kwon, Hong Bae Jeon, Soo Jin Choi, Seong Who Kim, Yoon Sun Yang, Wonil Oh, Jong Wook Chang.
Stem Cells | 2013-02-11
Co-transplantation of third-party umbilical cord blood-derived MSCs promotes engraftment in children undergoing unrelated umbilical cord blood transplantation.
This study reports that co-transplantation of Umbilical Cord Blood(UCB)-Mesenchymal Stem Cells(MSCs) in UCB transplanting patient can enhance engraftment of UCBT and decrease Transplantation Related Mortality(TRM).

· Issue information | Bone Marrow Transplant. 2013 Aug;48(8):1040-5.
· Co-author | SH Lee, MW Lee, KH Yoo, DS Kim, MH Son, KW Sung, H Cheuh, SJ Choi, W Oh, YS Yang, HH Koo.