Publications

Stem Cells | 2022-02-01
CD26 Inhibition Potentiates the Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence
CD26 is a potential novel target for the rejuvenation of senescent MSCs for their use in manufacturing MSC-based applications.

· Issue information | Front Cell Dev Biol. 2021; 9: 803645. Published online 2022 Feb 1. doi: 10.3389/fcell.2021.803645
· Co-author | Miyeon Kim, Jinyoung Go, Ji Hye Kwon, Hye Jin Jin, Yun Kyung Bae, Eun-Young Kim, Eun-Ju Chang, Soo Jin Choi and Seong Who Kim
SMUP-Cell | 2021-09-14
PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model
PTX-3 expression in injected SMUP-Cells, applied as a therapeutic strategy, reduced pain in an OA model.

· Issue information | Cells. 2021 Sep 14;10(9):2420. doi: 10.3390/cells10092420.
· Co-author | Minju Lee, Gee-Hye Kim, Miyeon Kim, Ji Min Seo, Yu Mi Kim, Mi Ra Seon, Soyoun Um, Soo Jin Choi, Wonil Oh, Bo Ram Song, Hye Jin Jin
Stem Cells | 2021-04-15
Positively correlated CD47 activation and autophagy in umbilical cord blood-derived mesenchymal stem cells during senescence
CD47 is a key player in autophagy and senescence to maintain and regulate the growth of MSCs, suggesting that CD47 may be a critical key marker for selection of effective stem cells in cell therapy.

· Issue information | Stem Cells Int. 2021 Apr 15;2021:5582792. doi: 10.1155/2021/5582792.
· Co-author | Gee-Hye Kim, Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Soyoun Um and Hye Jin Jin
Cord Blood | 2021-01-14
High Integrity and Fidelity of Long-Term Cryopreserved Umbilical Cord Blood for Transplantation
The high-viability recovery of long-term cryopreserved CB suggests that successful hematopoietic stem cell (HSC) transplantation and other clinical applications, which are suitable for treating incurable diseases, may be performed regardless of long-term storage.

· Issue information | J Clin Med. 2021 Jan 14;10(2):293. doi: 10.3390/jcm10020293.
· Co-author | Gee-Hye Kim, Jihye Kwak, Sung Hee Kim, Hee Jung Kim, Hye Kyung Hong, Hye Jin Jin, Soo Jin Choi, Wonil Oh, Soyoun Um
SMUP-Cell | 2021-01-03
Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling.
A small cell from UCB-MSCs exhibit delayed cellular senescence by inhibiting the process of TLR signaling-mediated senescence-associated secretory phenotype (SASP) activation.

· Issue information | Cells. 2021 Jan 3;10(1):63. doi: 10.3390/cells10010063.
· Co-author | Ji Hye Kwon, Miyeon Kim, Soyoun Um, Hyang Ju Lee, Yun Kyung Bae, Soo Jin Choi, Hyun Ho Hwang, Wonil Oh, Hye Jin Jin
Stem Cells | 2020-12-26
Prospects for the therapeutic development of umbilical cord blood-derived mesenchymal stem cells.
This article reviewed the current literature pertaining to the UCB-derived MSC application as potential treatment strategies, and discuss the concerns regarding the safety and mass production issues in future applications.

· Issue information | World J Stem Cells. 2020 Dec 26;12(12):1511-1528. doi: 10.4252/wjsc.v12.i12.1511.
· Co-author | Soyoun Um, Jueun Ha, Soo Jin Choi, Wonil Oh, Hye Jin Jin
Stem Cells | 2020-07-18
Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Aberrant Tau Phosphorylation in an Alzheimer Disease Model
hUCB-MSCs-secreted GAL-3 reduces Aberrant tau phosphorylation in AD model

· Issue information | Stem Cells Int. 2020 Jul 18;2020:8878412.doi:10.1155/2020/8878412
· Co-author | Hoon Lim, Dahm Lee, Wan Kyu Choi, Soo Jin Choi, Wonil Oh, Dong Hyun Kim
Others | 2020-05-28
Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth
Application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) improved hair growth and developed a method to reliably produce this optimized CM

· Issue information | Cells, 2020 May 28;9(6):1344. doi: 10.3390/cells9061344.
· Co-author | Hyun Ah Oh, Jihye Kwak, Beom Joon Kim, Hye Jin Jin, Won Seok Park, Soo Jin Choi, Wonil Oh, Soyoun Um
SMUP-Cell | 2020-04-28
A Small-Sized Population of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Shows High Stemness Properties and Therapeutic Benefit
A small-sized population of human UCB-MSC improved therapeutic effects in an elastase-induced emphysema model.

· Issue information | Stem Cells Int. 2020 Apr 28;2020:5924983. doi: 10.1155/2020/5924983.
· Co-author | Miyeon Kim, Yun Kyung Bae, Soyoun Um, Ji Hye Kwon, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Hye Jin Jin
Stem Cells | 2020-04-17
Primary cilia mediate Wnt5a/β-catenin signaling to regulate adipogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells following calcium induction
Ciliogenesis was negatively regulated by Wnt5a/β-catenin signaling during adipogenesis.

· Issue information | Tissue Eng Regen Med. 2020 Apr;17(2):193-202. doi: 10.1007/s13770-019-00237-4.
· Co-author | Yun Kyung Bae, Gee-Hye Kim, Ji Hye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin
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