Publications
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PNEUMOSTEM | 2021-04-20 Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial
In phase II clinical trial, intratracheal transplantation of PNEUMOSTEM might be safe and feasible, it did significantly improve the secondary outcome of severe BPD in preterm infants at 23 to 24 gestational weeks subgroup. Accordingly, we are now conducting an additional larger and controlled phase II clinical trial focusing on preterm infants at 23 to 24 gestational weeks.· Issue information | Stem Cells Transl Med. 2021 Aug;10(8):1129-1137. doi: 10.1002/sctm.20-0330. · Co-author | So Yoon Ahn, Yun Sil Chang, Myung Hee Lee, Se In Sung, Byong Sop Lee, Ki Soo Kim, Ai-Rhan Kim, Won Soon Park |
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PNEUMOSTEM | 2020-01-23 Soluble PTX3 of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Attenuate Hyperoxic Lung Injury by Activating Macrophage Polarization in Neonatal Rat Model
PTX3 is a potential marker with critical paracrine effects for predicting the therapeutic potential of MSC therapy in inflammatory diseases; quality-control assessments using PTX3 may be useful for improving the therapeutic effects of UCB-MSCs.· Issue information | Stem Cells Int. 2020, article ID 1802976. https://doi.org/10.1155/2020/1802976 · Co-author | Miyeon Kim, Ji Hye Kwon, Yun Kyung Bae, Gee-Hye Kim, Soyoun Um, Jueun Ha, Soo Jin Choi, Wonil Oh, Hye Jin Jin |
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PNEUMOSTEM | 2019-09-27 Decorin Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Induces Macrophage Polarization via CD44 to Repair Hyperoxic Lung Injury
Decorin as a key paracrine factor, including macrophage polarization via CD44, a master immunoregulator in human UCB-MSCs.· Issue information | Int J Mol Sci. 2019 Sep 27;20(19). pii: E4815. doi: 10.3390/ijms20194815. · Co-author | Ji Hye Kwon, Miyeon Kim, Yun Kyung Bae, Gee Hye Kim, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin |
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PNEUMOSTEM | 2019-04-13 Safety of Intratracheal Administration of Human Umbilical Cord Blood Derived Mesenchymal Stromal Cells in Extremely Low Birth Weight Preterm Infants
Intratracheal administration of PNEUMOSTEM treatment was well tolerated and shows to be safe and feasible in extremely low birth weight preterm Infants at high risk for bronchopulmonary dysplasia.· Issue information | J Pediatr. 2019 Jul;210:209-213.e2. doi: 10.1016/j.jpeds.2019.02.029. · Co-author | So Yoon Ahn, Yun Sil Chang, Ji Hye Kim, Se In Sung, Won Soon Park |
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PNEUMOSTEM | 2017-04-21 Two-Year Follow-Up Outcomes of Premature Infants Enrolled in the Phase I Trial of Mesenchymal Stem Cells Transplantation for Bronchopulmonary Dysplasia
Intratracheal transplantation of PNEMOSTEM in preterm infants enrolled in the Phase I Trial has been shown to be safe, with no adverse respiratory, growth, and neurodevelopmental effects at 2 years follow-up.· Issue information | J Pediatr. 2017 Jun;185:49-54.e2. doi: 10.1016/j.jpeds.2017.02.061 · Co-author | So Yoon Ahn, Yun Sil Chang, Ji Hye Kim, Se In Sung, Won Soon Park |
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PNEUMOSTEM | 2014-02-06 Mesenchymal Stem Cells for Bronchopulmonary Dysplasia: Phase 1 Dose-Escalation Clinical Trial
In phase I clinical trial, Intratracheal transplantation of PNEMOSTEM in preterm infants at high risk for bronchopulmonary dysplasia was shown to be safe and feasible.· Issue information | J Pediatr. 2014 May;164(5):966-972.e6. doi: 10.1016/j.jpeds.2013.12.011 · Co-author | Yun Sil Chang, So Yoon Ahn, Hye Soo Yoo, Se In Sung, Soo Jin Choi, Won Il Oh, Won Soon Park |
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PNEUMOSTEM | 2013-01-21 Timing of Umbilical Cord Blood Derived Mesenchymal Stem Cells Transplantation Determines Therapeutic Efficacy in the Neonatal Hyperoxic Lung Injury.
This study reports experimental results for timing of umbilical cord blood derived mesenchymal stem cells administration into airway in broncho-pulmonary dysplasia that when it is transplanted intratracheally, it is possible to obtain statistically significant therapeutic effect.· Issue information | PLoS One. 2013;8(1):e52419. · Co-author | YS Chang, SJ Choi, SY Ahn, DK Sung, SI Sung, HS Yoo, W Oh, WS Park. |
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PNEUMOSTEM | 2011-08-01 Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice.
This study shows results that intratracheal transplantation of umbilical cord blood derived mesenchymal stem cells in acute lung injury by bacteria can mitigate the injury by promoting anti-inflammatory reaction and bacterial removal.· Issue information | Respir Res. 2011 Aug 15;12:108. · Co-author | ES Kim, YS Chang, SJ Choi, JK Kim, HS Yoo, SY Ahn, DK Sung, SY Kim, YR Park, WS Park. |
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PNEUMOSTEM | 2011-01-01 Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Dose-Dependently Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats.
This study shows results that intratracheal transplantation of human UCB derived MSCs may attenuate hyperoxia-induced lung injury in neonatal rats by modulating host inflammatory responses and oxidative stress.· Issue information | Cell Transplant. 2011;20(11-12):1843-54. · Co-author | YS Chang, SJ Choi, DK Sung, SY Kim,W Oh, YS Yang, WS Park. |